哺乳动物单倍体胚胎干细胞研究进展与展望

doi:10.11843/j.issn.0366-6964.2013.09.002

畜牧兽医学报 ›› 2013, Vol. 44 ›› Issue (9): 1342-1348.doi: 10.11843/j.issn.0366-6964.2013.09.002

哺乳动物单倍体胚胎干细胞研究进展与展望

赵海龙¹，赵永聚²，杨丽群¹，向仲怀¹，崔红娟^1*

^{(1. 西南大学,家蚕基因组生物学国家重点实验室，重庆 400715； 2.西南大学动物科技学院，重庆 400715）}

收稿日期:2013-03-22 出版日期:2013-09-23 发布日期:2013-09-23
通讯作者: 崔红娟，教授，E-mail：hongjuan.cui@gmail.com
作者简介:赵海龙(1988-)，男，蒙族，河北人，博士，主要从事干细胞生物学的研究，E-mail: 659846959@qq.com，Tel：023-68251712
基金资助:
国家重点基础研究发展计划“973”项目（2012CB114603）；国家自然科学基金面上项目（31172268；31271462）

The Recent Research Progress and Outlook of Haploid Stem Cell in Mammals

ZHAO Hai-long¹, ZHAO Yong-ju², YANG Li-qun¹, XIANG Zhong-huai¹, CUI Hong-juan^1*

(1. State Key Laboratory of Silkworm Genome Biology，Southwest University，Chongqing 400715, China; 2. College of Animal Science and Technology, Southwest University,Chongqing 400715, China)

Received:2013-03-22 Online:2013-09-23 Published:2013-09-23

摘要/Abstract

摘要：

单倍体胚胎干细胞（Haploid embryonic stem cells，haES）是指只含有一套染色体的，拥有类似于正常胚胎干细胞的特性，可以在体外无限增殖，并可以形成多种功能细胞、组织和器官的细胞类群，现阶段分为孤雌单倍体胚胎干细胞和孤雄单倍体胚胎干细胞2种。单倍体胚胎干细胞经过2年多的发展已成为研究基因遗传功能的理想工具，而且在细胞水平与个体水平上均体现强大的潜力。本文将从近期研究进展、应用方向及存在的问题等3个主要方面对哺乳动物单倍体干细胞进行系统的介绍，并结合笔者的观点对其未来的发展前景予以展望。

Abstract:

Haploid embryonic stem (haES) cells contain one single set of chromosome and share some characteristics of normal embryonic stem cells, including the ability of self-renewal in vitro and forming multiple functional cells of all the tissues and organs. Recent studies demonstrate that haES cells are divided into parthenogenetic and androgenetic mouse embryos. Abundant data and evidence show that haES could be used as an ideal tool for genetic analyses. Here, we summary the recent progresses, potential applications, and some limitations of the mammalian haES. We also provide some viewpoints about haES combined with our study.

中图分类号:

赵海龙，赵永聚，杨丽群，向仲怀，崔红娟. 哺乳动物单倍体胚胎干细胞研究进展与展望[J]. 畜牧兽医学报, 2013, 44(9): 1342-1348.

ZHAO Hai-long, ZHAO Yong-ju, YANG Li-qun, XIANG Zhong-huai, CUI Hong-juan. The Recent Research Progress and Outlook of Haploid Stem Cell in Mammals[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(9): 1342-1348.

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哺乳动物单倍体胚胎干细胞研究进展与展望

The Recent Research Progress and Outlook of Haploid Stem Cell in Mammals

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